By eliminating preservating binding
Your choice of filter membrane for sterilizing ophthalmic products can have a major impact on the economy of your system. Parker domnick hunter can offer filtration products that not only guarantee product sterility but are also designed to minimize preservative binding for reduced product loss.
The problem
Product loss due to preservative binding during filtration stages is a major concern in ophthalmic solution production. Membrane chemistry can have a significant effect on preservative binding properties. The choice of filtration membrane is critical in reducing the amount of product wastage through binding and therefore total processing costs.
The solution
The hydrophilic PTFE membrane used in our innovative TETPOR HP filter product consistently outperforms other membrane materials when it comes to low preservative adsorption. Tests conducted using common preservatives benzalkonium chloride (BAK) and polyhexamethylene biguanide (PHMB) have shown this to be true even when compared to PES or PVDF, which are well known for their low binding characteristics. The TETPOR HP can completely eliminate preservative binding, minimizing product loss and ensuring costeffective processing.
Comparison of product loss due to preservative binding on different filter membranes for a 0.001% solution of benzalkonium chloride (BAK)
* The relative volume of product loss represents the volume at which the concentration of BAK in the filtrate recovers back to 95% of the original concentration, which is typically the point at which the filling operation can begin.
Tetpor HPTETPOR HP filter cartridges have been specifically designed to minimise preservative binding for economic sterilisation of multidose ophthalmic solutions.
